SCyCode-related publications

Below is a publication record from our studies since 2018.


Kraus A., Spät P., Timm S., Wilson A., Schumann R., Hagemann M., Maček B., Hess W.R. (2024) Protein NirP1 regulates nitrite reductase and nitrite excretion in cyanobacteria. Nature Communications 15, 1911. DOI: 10.1038/s41467-024-46253-4.


Zittlau K., Nashier P., Cavarischia-Rega C., Macek B., Spät P., Nalpas N. 2023. Recent progress in quantitative phosphoproteomics. Exp Rev Proteomics 20(12):469-482. DOI 10.1080/14789450.2023.2295872

Barske T., Spät P., Schubert H., Walke P., Maček B., Hagemann M. (2023) The role of serine/threonine-specific protein kinases in cyanobacteria - SpkB is involved in acclimation to fluctuating conditions in Synechocystis sp. PCC 6803Molecular & Cellular Proteomicsdoi10.1016/j.mcpro.2023.100656

Böhm J., Kauss K., Michl K., Engelhardt L., Brouwer E.M., Hagemann M. (2023) Impact of the carbon flux regulator protein pirC on ethanol production in engineered cyanobacteria. Front. Microbiol. 14: 1238737. DOI 10.3389/fmicb.2023.1238737.

Spät P., Krauspe V., Hess W.R., Maček B., Nalpas N. (2023) Deep Proteogenomics of a Photosynthetic Cyanobacterium. Journal of Proteome Research. doi: 10.1021/acs.jproteome.3c00065


Lucius S., Theune M., Arrivault S., Hildebrandt S., Mullineaux C.W., Gutekunst K., Hagemann M. (2022) CP12 fine-tunes the Calvin-Benson cycle and carbohydrate metabolism in cyanobacteria. Front. Plant Sci. 13:1028794. doi: 10.3389/fpls.2022.1028794

Doello S., Neumann N.Forchhammer K. (2022) Regulatory phosphorylation event of phosphoglucomutase 1 tunes its activity to regulate glycogen metabolism.

Wang Y., Chen X., Spengler K., Terberger K., Boehm M., Appel J., Barske T., Timm S., Battchikova N., Hagemann M., Gutekunst K. (2022) Pyruvate:ferredoxin oxidoreductase and low abundant ferredoxins support aerobic photomixotrophic growth in cyanobacteria. eLife 11:e71339. doi: 10.7554/eLife.71339


Scheurer NM., Rajarathinam Y., Timm S., Kopka J., Hagemann M., Wilde A. (2021) Homologs of circadian clock proteins impact the metabolic switch between light and dark growth in the cyanobacterium Synechocystis sp. PCC 6803. Front Plant Sci 12: 657227. doi: 10.3389/fpls.2021.675227

Lucius S., Makowka A., Michl K., Gutekunst K., Hagemann M. (2021) The Entner-Doudoroff pathway contributes to glycogen breakdown during high to low CO2 shifts in the cyanobacterium Synechocystis sp. PCC 6803. Front Plant Sci 12: 787943; doi: 10.3389/fpls.2021.787943

Oren N., Timm S., Frank M., Mantovani O., Murik O., Hagemann M. (2021) Red/far-red light signals regulate the activity of the carbon-concentrating mechanism in cyanobacteria. Sci Adv 7, eabg0435.

Semanjski, M., Gratani, F.L., Englert, T., Nashier, P., Beke, V., Nalpas, N., Germain, E., George, S., Wolz, C., Gerdes, K., Maček, B. (2021) Proteome Dynamics during Antibiotic Persistence and Resuscitation. mSystems.

Spät, P., Barske, T., Maček, B. and Hagemann, M. (2021) Alterations in the CO2 availability induce alterations in the phosphoproteome of the cyanobacterium Synechocystis sp. PCC 6803. New Phytol.

Orthwein T., Scholl J., Spät P., Lucius S., Koch M., Maček B., Hagemann M., Forchhammer K. (2021) The novel PII-interactor PirC identifies phosphoglycerate mutase as key control point of carbon storage metabolism in cyanobacteria. Proc. Natl. Acad. Sci. USA (PNAS) 118: e2019988118.

Riediger M., Spät P., Bilger R., Voigt K., Maček B., Hess W.R. (2021) Analysis of a photosynthetic cyanobacterium rich in internal membrane systems via gradient profiling by sequencing (Grad-seq). The Plant Cell 10.1093/plcell/koaa017

Bolay P., Rozbeh R., Muro-Pastor MI., Timm S., Hagemann M., Florencio FJ., Forchhammer K., Klähn S. (2021) The novel PII-interacting protein PirA controls flux into the cyanobacterial ornithine-ammonia cycle. mBio, 10.1101/2020.11.23.395327

Doello, S., Burkhardt, M., Forchhammer, K. (2021) The essential role of sodium bioenergetics and ATP homeostasis in the developmental transitions of a cyanobacterium. Curr Biol. 10.1016/j.cub.2021.01.065

Krauspe V., Fahrner M., Spät P., Steglich C., Frankenberg-Dinkel N., Maček B., Schilling O., Hess W.R. (2021) Discovery of a small protein factor involved in the coordinated degradation of phycobilisomes in cyanobacteria. Proc. Natl. Acad. Sci. USA (PNAS) 118: e2012277118

Zhan J., Steglich C., Scholz I., Hess W.R., Kirilovsky D. (2021) Inverse regulation of light harvesting and photoprotection mediated by a 3'end-derived sRNA in cyanobacteria. The Plant Cell, Volume 33, Issue 2, February 2021, Pages 358–380

Hagemann M., Song S., Brouwer EM. (2021) Inorganic carbon assimilation in cyanobacteria: Mechanisms, regulation, and engineering. In Hudson P (ed) Cyanobacteria Biotechnology, Wiley, Chapter 1, in press

Schmelling NM., Scheurer N., Köbler C., Wilde A., Axmann IM. Diversity of timing systems in Cyanobacteria and beyond. In: Circadian Rhythms in Bacteria and Microbiomes, Springer Nature, eds. Johnson C and Rust M., 978-3-030-72157-2, in press (book publication)


Makowka, A., Nichelmann, L., Schulze, D., Spengler, K., Wittmann, C., Forchhammer, K,  Gutekunst K. (2020) Glycolytic Shunts Replenish the Calvin–Benson–Bassham Cycle as Anaplerotic Reactions in Cyanobacteria. Molecular plant 13: 471-482

Koch, M., Bruckmoser, J., Scholl, J., Hauf, W. Rieger, B. and Forchhammer, K. (2020) Maximizing PHB content in Synechocystis sp. PCC 6803: a new metabolic engineering strategy based on the regulator PirC. Microb Cell Fact 19: 231

Wiegard A., Köbler C., Oyama K., Dörrich AK., Azai C., Terauchi K., Wilde A., Axmann IM. (2020) Synechocystis KaiC3 displays temperature and KaiB dependent ATPase activity and is important for growth in darkness. J. Bacteriol. 202, e00478-19.

Appel, J., Hueren, V., Boehm, M., Gutekunst, K. (2020) Cyanobacterial in vivo solar hydrogen production my means of a photosystem I-hydrogenase (psaD-hoxYH) fusion complex. Nature Energy

Theune, M. L., Hildebrandt, S., Steffen-Heins, A., Bilger, W., Gutekunst, K., Appel, J. (2020) In-vivo quantification of electron flow through photosystem I – Cyclic electron transport makes up about 35% in a cyanobacterium. Biochimica et Biophysica Acta (BBA) – Bioenergetics

Lambrecht J.S., Steglich C., Hess W.R. (2020) A minimum set of regulators to thrive in the ocean. FEMS Microbiology Reviews 44: 232-252

Muro-Pastor A.M., Hess W.R. (2020) Regulatory RNA at the crossroads of carbon and nitrogen metabolism in photosynthetic cyanobacteria. BBA - Gene Regulatory Mechanisms 1863, 194477: 1-12 


Koch, K. Doello, S. Gutekunst, K., Forchhammer, K. (2019) PHB is produced from Glycogen turn-over during nitrogen starvation in Synechocystis sp. PCC 6803. (2019) Int. J. Mol. Sci. 20 (8): 1942

Maček B., Forchhammer K., Hardouin J., Weber-Ban E., Grangeasse C., Mijakovic I. 2019. Protein post-translational modifications in bacteria. Nat Rev Microbiol 17 (11), 651-66


Köbler C., Schultz SJ., Kopp D., Voigt K., Wilde A. (2018) The role of the Synechocystis sp. PCC 6803 homolog of the circadian clock output regulator RpaA in day-night transitions. Mol. Microbiol. 110, 847-861.

Gutekunst, K. (2018) Hypothesis on the Synchronistic Evolution of Autotrophy and Heterotrophy. Trends in Biochemical Sciences 43: 402-411